Value of atropine test combining 24 h Holter in predicting risk of sudden death in patients with sinus bradyarrhythmia
XIAO Shi-nan
YU Chao-yang
WANG Wen-jun
Abstract：Objective To study the effect of atropine test combining 24 h ambulatory electrocardiograph monitoring (Holter) in predicting risk of sudden death in patients with sinus bradyarrhythmia.Methods The patients (n=64) were chosen from the Department of Heart and Kidney of Chinese PLA First Hospital from Feb. 2011 to Mar. 2015, and all of them was implanted permanent pacemakers. The patients were given 24 h Holter for observing cardiac impulse, and injected intravenously atropine in extended 1 h. The changes of maximum heart rate (HR) were recorded particularly. The risk of sudden death was analyzed and reviewed through the outcomes of HR in the slowest period showed by 24 h Holter.Results Among all patients, there were 21 with HR<45/min in the minimum time, and 43 with HR from 40 to 60/min in the minimum time. After atropine test during extended 1 h, there were 42 cases with the maximum HR>85/min (negative), and 22 with the maximum HR<85/min (positive), which were taken for reviewing the risk of sudden death in all patients and grouping. There were totally 13 cases died (20.3%) and fatality rate had significant difference among all groups (P<0.05).Conclusion Atropine provocative test combining 24 h Holter has predictive value to the risk of sudden death in patients with sinus bradyarrhythmia. During 1 h atropine provocative test, if patients’ HR is lower than 85/min, they will have higher risk of sudden death and they should be extra vigilant. Permanent pacemakers can decrease the risk of sudden death.
Keywords：Sinus bradyarrhythmiaAtropine24 h HolterSudden death
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 1249-1250 )