Influence of different-dose clopidogrel pretreatment on percutaneous coronary intervention

ZHAO Shi-ming; FAN Meng-meng; HE Lei

doi:10.3969/j.issn.1674-4055.2016.10.16

Abstract：Objective To observe the influence of different-dose clopidogrel pretreatment on platelet aggregation rate (PAG) and myocardial enzyme indexes before percutaneous coronary intervention (PCI).Methods The patients undergone PCI (n=90) were chosen from Jan. 2013 to Jan. 2015, and divided into high-dose group and low-dose group according to the doses of clopidogrel pretreatment. The low-dose group was given 300 mg of clopidogrel and high-dose group was given 600 mg of clopidogrel at admission time, and then 2 groups were given 75 mg of clopidogrel as maintain dose every day. The changes of PAG before PCI and myocardial enzyme indexes after PCI were observed in 2 groups.Results In low-dose group, PAG was (50.4±10.6)%, (48.3±9.8)%, (45.4± 8.8)%, (45.9±8.6)% and (42.2±7.6)%, respectively, after drug taking for 2 h, 4 h, 6 h, 24 h, and 72 h. In high-dose group, PAG was (45.2±9.2)%, (43.5±9.3)%, (41.0±8.1)%, (41.3±8.3)% and (41.0±7.9)%, respectively, after drug taking for 2 h, 4 h, 6 h, 24 h, and 72 h. PAG was significantly lower in high-dose group than that in low-dose group after taking drug for 2 h, 4 h, 6 h and 24 h (P<0.05). After PCI, the levels of creatine kinase (CK), creatine kinase MB (CK-MB) and lactic dehydrogenase (LDH) were, respectively, (385.6±55.3) IU/L, (52.1± 8.3) IU/L, (474.5±68.0) IU/L in low-dose group, and (319.4±49.7) IU/L, (45.9±7.2) IU/L, (395.7±48.6) IU/L in high-dose group (P<0.05).Conclusion The clopidogrel pretreatment in a higher dose before PCI can significantly decrease PAG, and effective improve myocardial enzyme indexes in patients undergone PCI.