Relationship between serum lipoprotein-a and coronary heart disease

QIAN Qi; JIANG Hai; GUO Shou-yu; XU Shao-hua; LONG Ming-zhi

doi:10.3969/j.issn.1674-4055.2016.10.14

Abstract：Objective To detect the changes of serum lipoprotein-a (Lp-a) in patients with coronary heart disease (CHD), and discuss the relationship between Lp-a and CHD.Methods The patients (n=419, male 210 and female 209) hospitalized due to chest pain were chosen from the Department of Cardiology of Second Affiliated Hospital of Nanjing Medical University from Feb. 2013 to Jan. 2016. According to the outcomes of coronary angiograph (CAG), the patients were divided into CHD group (decrease of at least 1 coronary vessel diameter≥50%,n=189) and control group (decrease of coronary vessel diameter<50%,n=230). CHD group was divided again, according to numbers of diseased coronary vessels, into 1-vessel group (n=101), 2-vessel group (n=41) and 3-vessel group (n=47). The blood samples were collected from all patients for detecting the level of serum Lp-a, and at the same time the levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C) and fasting blood glucose (FBG) were detected.Results Compared with control group, the patients were older with higher percentages of history of diabetes, hypertension, hyperlipidemia and smoking in CHD group (all P<0.01). The levels of serum TC, LDL-C and LP-a were significantly higher in CHD group than those in control group (allP<0.05). Besides of traditional risk factors (history of diabetes, hyperlipidemia and smoking, and LDL-C), TC (OR=2.531, 95%CI: 1.783~3.594) and Lp-a (OR=1.006, 95%CI: 1.004~1.008) were the most significant independent risk factors of CHD. The level of serum LP-a was (462.34±275.39) mmol/L in 3-vessel group, which was significantly higher than that in 1-vessel group (251.63±139.99) mmol/L and 2-vessel group (413.90±184.14) mmol/L. The level of serum LP-a was higher in 2-vessel group than that in 1-vessel group (allP<0.01).Conclusion The level of serum LP-a is correlated to the severity of CHD and coronary artery lesions.