Relationship between homocysteine or gene polymorphisms of methylenetetrahydrofolate reductase and essential hypertension complicating coronary heart disease in elderly patients
ZHAO Yan-mei
WANG Dong-xu
XU Wei-yan
LIN Jing-jing
HUANG Cui-juan
WANG Zheng-dong
LIANG Ping
Abstract：Objective To discuss the relationship between homocysteine (Hcy) or gene polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and essential hypertension complicating coronary heart disease (CHD) in elderly patients.Methods The patients with essential hypertension (n=200, male 115, female 85 and average age=67.52±3.53) were chosen from the Department of Cardiology of First People’s Hospital of Yulin City from Feb. 2014 to Feb. 2015. The patients were divided, according to outcomes of coronary angiography (CAG), into hypertension group and CHD group (eachn=100). At the same time, healthy controls (n=100) were chosen as control group. The genotypes of MTHFR C677T were detected by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method and Hcy level was detected meanwhile in 3 groups.Results Compared with control group, blood pressure, triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C) and Hcy increased in hypertension group and CHD group (allP<0.05). In hypertension group, the frequency was 27.0% in CC genotype, 50.0% in CT genotype and 23.0% in TT genotype, and frequency was 52.0% in C allele and 48.0% in T allele at MTHFR C677 locus. In CHD group, the frequency was 12.0% in CC genotype, 55.0% in CT genotype and 33.0% in TT genotype, and frequency was 39.5% in C allele and 60.5%in T allele. In control group, the frequency was 40.0% in CC genotype, 45.0% in CT genotype and 15.0% in TT genotype, and frequency was 62.5% in C allele and 37.5% in T allele. The frequency of TT genotype and frequency of T allele were higher in CHD group than those in hypertension group and control group (allP<0.05). Hcy level was higher in TT genotype than that in CC genotype and CT genotype in CHD group (allP<0.05).Conclusion TT genotype of MTHFR C677T maybe an important genetic risk factor, and T allele maybe a risk allele for CHD in elderly patients with essential hypertension.
Keywords：HomocysteineMethylenetetrahydrofolate reductaseGene polymorphismsSenile essential hypertensionCoronary heart disease
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1191-1194 )