The protective effect of recombinant human brain natriuretic peptide on heart and renal function after rheumatic heart valve replacement
SONG Shu-tian
YANG Ming
LI Kun-peng
XU Juan
BAI Chuan-ming
ZHOU Ji-wu
Abstract：Objective To investigate protective effect of recombinant human brain natriuretic peptide on heart and renal function after rheumatic heart valve replacement.Methods 70 patients undergoing rheumatic heart valve replacement from October 2014 to October 2015 in Cangzhou Central Hospital were divided into experimental group (35 cases) and control group (35 cases) randomly. Intravenous-inhalational anesthesia was administered, and the vital signs of patients were paid close attention during the operation. After operation, control group was administered dopamine, epinephrine and intravenous infusion of nitroglycerin; the experimental group were treated with recombinant human brain natriuretic peptide on the basis of the control group. The changes of cardiac and renal function in two groups before and after operation were observed, and adverse events were observed during one-month follow-up.Results After treatment, N-terminal B-type natriuretic peptide (NT-proBNP) in experimental group was lower than control group [(1072.54±245.81) ng/Lvs. (1384.52±391.77)ng/L,P<0.01], the level of Left ventricular ejection fraction (LVEF) was higher in experimental group [(53.81±6.28)%vs. (46.19±5.92)%, P<0.01]; the level of glomerular filtration rate (GFR) higher in experimental group [(75.18±17.31)ml/minvs. (62.71 ±15.62)ml/min,P<0.01]; blood urea nitrogen (BUN) was lower in experimental group [(6.24±1.35)μmol/Lvs. (9.07±1.68)μmol/L,P<0.01]; Serum creatinine (SCr) was lower in experimental group [(116.74±24.40)μmol/L vs. (129.56±25.76)μmol/L,P<0.05]; 24 hours urine volume was higher in experimental group [(1650±235)mlvs. (1430±201)ml,P<0.01]. There was no statistically significant difference in the incidence of adverse events (P>0.05). Conclusion The use of recombinant human brain natriuretic peptide before rheumatic heart valve replacement is better, and can protect cardiac and renal function of patients.
Keywords：Recombinant human brain natriuretic peptideCardiac valve replacementHeart functionRenal function
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1185-1187 )