Brief introduction of genetic association studies and corresponding Meta-analysis
WENG Hong
LI Miao-zhu
GENG Pei-liang
ZENG Xian-tao
Abstract：Gene plays an important role in the development and progression of diseases. The genetic association study is one of the vital approaches in the field of association between gene and complex diseases in human. However, a “winner’s curse” phenomenon is existed in the field of association study. In addition, the effect of each gene is relatively mild, therefore, large size sample studies are warranted to detect the true gene effect. The aim of this paper is to give a brief introduction of methods and reporting guideline of the genetic association studies and corresponding Meta-analyses.
Keywords：Candidate geneGenetic association studyGene polymorphismMeta-analysis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1156-1158 )