Influence of paeonol on coronary atherosclerosis
LI Qian-kuan
ZHENG Xiao-ran
GONG Ming-yu
FAN Yan-fang
QU Jing-yang
ZHOU Xiao-hui
Abstract：Objective To discuss the influence of paeonol on coronary atherosclerosis in rats.Methods Male healthy SD rats (n=46) were chosen and randomly divided into 6 groups: normal group (normal forage and normal saline solution for 8 w,n=7), model group (25 g/rat/d of high-fat forage for 8 w and normal saline solution for 8 w,n=8), low-dose group (25 g/rat/d of high-fat forage for 8 w and 30 mg/kg·d of paeonol for 8 w,n=8), mid-dose group (25 g/rat/d of high-fat forage for 8 w and 60 mg/kg·d of paeonol for 8 w,n=8), high-dose group (25 g/rat/d of high-fat forage for 8 w and 120 mg/kg·d of paeonol for 8 w,n=8) and control group (25 g/rat/d of high-fat forage for 8 w and 10 mg/kg·d of simvatatin for 8 w,n=7). The expressions of GAPDH, intercellular adhesion molecule-1 (ICAM-1), vascular adhesion molecule-1 (VCAM-1) and monocyte chemoattractant protein-1 (MCP-1) were detected by using real-time fluorescence quantitative polymerase chain reaction (RT-PCR) and agarose gel electrophoresis. The levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein-cholesterol (LDL-C) and high-density lipoprotein-cholesterol (HDL-C) were detected by using automatic biochemical analyzer.Results Compared with normal group, the levels of TC, TG and LDL-C and ratio of LDL-C to HDL-C increased, and level of HDL-C decreased in model group (allP<0.05). Compared with model group, all blood fat indexes were improved in control group and in high-dose group at the same time (allP<0.05). The level of TC and ratio of LDL-C to HDL-C decreased in mid-dose group compared with model group (allP<0.05). The expressions of ICAM-1, VCAM-1 and MCP-1 increased in model group compared with control group (allP<0.05). Compared with model group, the expressions of ICAM-1, VCAM-1 and MCP-1 decreased in control group and high-dose group (all P<0.05).Conclusion Paeonol in high dose can significantly improve blood fat indexes, reduce the expressions of chemotactic factors related to coronary atherosclerosis and decrease risk of coronary atherosclerosis.
Keywords：PaeonolCoronary atherosclerosisChemotactic factorsInflammation
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1037-1039 )