Influence of simvastatin combining aspirin on early atherosclerosis complicated with vascular endothelial dysfunction
WU Yun-tao
YAO Lu
TIAN Guo-xiang
ZHANG Wei
XIA Chang-quan
LIU Hui
WANG Xiao-bing
GAO Ying-chun
Abstract：Objective To analyze the interventional effect of simvastatin combining aspirin in patients with early atherosclerosis complicated with vascular endothelial dysfunction.Methods The male patients (n=167) were chosen from the Outpatient Department of the Chinese PLA Army General Hospital from Jan. 2011 to Jan. 2013. All patients were divided, according to their blood fat levels, into group 1 (n=57, LDL-C≥3.4 mmol/L, and given 40 mg/d of simvastatin and 100 mg/d of aspirin for 12 m), group 2 (n=65, 2.6 mmol/L≤LDL-C<3.4 mmol/L, and given 20 mg/d of simvastatin and 100 mg/d of aspirin for 12 m), and control group (n=45, LDL-C<2.6 mmol/L and not given simvastatin and aspirin). The brachial artery flow-mediated dilation (FMD), intima-media thickness (IMT) of carotid artery, abdominal aorta and lower limb artery and nitroglycerin-mediated dilatation (NMD) were detected by using color Doppler ultrasonic diagnostic apparatus before and 12 m after medication. The levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) were detected.Results After treatment, IMT decreased in group 1 and group 2, and increased in control group (allP<0.05). After treatment, the levels of LDL-C and TC decreased significantly in group 1 and group 2 (allP<0.05). The brachial artery FMD increased in group 1 and group 2 after treatment (allP<0.05). Compared with control group, the brachial artery FMD increased in group 1 and group 2 after treatment (allP<0.05). The comparison in NMD showed no statistical significance among 3 groups (allP>0.05).Conclusion Simvastatin combining aspirin can reverse early atherosclerosis in patients with early atherosclerosis complicated with vascular endothelial dysfunction, and its effective mechanism maybe related to the decreases of TC, TG and LDL-C but there is no significant dose-effect relationship. The effect maybe independent of lipid-lowering effect, which can be considered to be related to the improvement of vascular endothelial function.
Keywords：Vascular endothelial functionSimvastatinAspirinAtherosclerosis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1033-1036 )