The application of different administrated duration of tirofiban in the patients with acute myocardial infarction
YOU Cui-fang
LUO Rui-ying
Abstract：Objective To investigate the clinical effects of different administrated duration of tirofiban on the acute myocardial infarction (AMI) patients in perioperative period of percutaneous coronary intervention (PCI). Methods 108 AMI patients who were treated in the affiliated Ningde city hospital of Fujian Medical University and received PCI from May 2012 to May 2014, were divided into three groups randomly: 48 h group [with tirofiban loading dose 0.4μg/(kg·min) for 30 min and then 0.1μg/(kg·min) for 48 h], 24 h group [with tirofiban loading dose 0.4μg/(kg·min) for 30 min and then 0.1μg/(kg·min) for 24 h] and the control group. Each group have 36 patients. The platelet count and platelet aggregation rate before and after treatment were compared among three groups to verify the risk of thrombus and bleeding. Left ventricular end systolic diameter (LVESD), minor shrinkage (FS) and left ventricular ejection fraction (LVEF) were measured in order to verify the incidence of major adverse cardiovascular events case (MACE) of each group.Results The platelet count and platelet aggregation of 48 h group were significantly lower than 24 h group (P<0.05). There were no significant difference with respect to LVESD, FS, LVEF and the incidence rate of bleeding events among three groups after treatment (P>0.05).Conclusion Tirofiban in 48 h group can effectively inhibit function of platelet, reduce the incidence of MACE in patients with AMI after PCI.
Keywords：Acute myocardial infarctionPercutaneous coronary interventionPerioperativeTirofiban
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 986-988 )