Correlation analysis between TWEAK and receptor with coronary heart disease
ZHAO Li
Abstract：Objective To investigate the expression and clinical significance of TNF-like weak inducer of apoptosis (TWEAK) and its receptor soluble CD163 in peripheral blood of patients with coronary heart disease (CHD). Methods 154 CHD patients diagnosed by coronary angiography between January 2015 and January 2016 from Dongguan Branch of Yan'an University Affiliated Hospital with in patients were selected as case group, including 98 males, 56 females, with mean age of 64.8±10.2 years. 50 normal subjects were selected as control group, including 33 males and 17 females, with mean age of 62.3±11.0 years. The levels of soluble TWEAK and soluble CD163 in peripheral blood was detected by ELISA method.Results Levels of soluble TWEAK and soluble CD163 in peripheral blood of acute myocardial infarction (AMI) patients, unstable angina pectoris (UAP) patients, or stable angina pectoris (SAP) patients, patients of normal group were significantly different (P<0.05). Levels of soluble TWEAK and soluble CD163 of AMI patients were significantly higher than UAP and SAP patients and normal group (P<0.05). Levels of soluble TWEAK and soluble CD163 of UAP and SAP patients were significantly higher than normal group (P<0.05). The Gensini score of AMI, UAP and SAP patients showed a gradual decreasing trend and were significantly different (P<0.05). There was a significant positive correlation between soluble TWEAK, soluble CD163 level and Gensini score in peripheral blood of CHD patients (P<0.05).Conclusion Peripheral blood soluble TWEAK, soluble CD163 were significantly elevated in CHD patients, and were related to the severity of the patient's condition.
Keywords：Coronary heart diseaseTumor necrosis factor-like weak inducer of apoptosis factorSoluble CD163
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 983-985 )