Clinical efficacy of lipoic acid injection on peripheral neuropathy in elderly patient with type 2 diabetes mellitus
YAO Lu
LIU Hui
TIAN Guo-xiang
WU Yun-tao
ZHANG Feng
Abstract：Objective To observe the clinical efficacy of lipoic acid injection on peripheral neuropathy (PNP) in elderly patient with type 2 diabetes mellitus (T2DM).Methods The elderly T2DM patients with PNP (n=60) were chosen from the Chinese PLA Army General Hospital from Dec. 2013 to Feb. 2015, and randomly divided into observation group and control group (eachn=30). The observation group was treated with lipoic acid injection, cobamamide and Danhong Injection, and control group was treated with cobamamide and Danhong Injection for 3 w. The curative effect, changes of nerve conduction velocity (NCV) including motor nerve NCV and sensory nerve NCV and adverse reactions were compared in 2 groups before and after treatment.Results The total effective rate was higher in observation group than that in control group (P<0.05). NCV increased significantly in 2 groups after treatment (P<0.05). The improvement effect of median nerve was better in observation group than that in control group (P<0.05), but improvement effect of common peroneal nerve had no significant difference between 2 groups (P>0.05). There were no adverse reactions observed in 2 groups.Conclusion Lipoic acid injection is safe and effective in treatment of PNP) in elderly patient with T2DM, which has good application prospect in clinic.
Keywords：Lipoic acid injectionDanhong InjectionCobamamideDiabetic peripheral neuropathy
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 977-978,982 )