Influence of levosimendan on heart function and myocardial injury in patients with chronic heart failure XU

Feng-lan; YANG Guan-quan; ZHAO Yan

doi:10.3969/j.issn.1674-4055.2016.08.25

Abstract：Objective To study the influence of levosimendan on myocardial injury and heart function in patients with chronic heart failure (CHF).Methods CHF patients (n=70, male 39, female 31 and aged from 53 to 76) were chosen from Dongda Hospital in Shan Country of Shandong Province from Mar. 2014 to Jan. 2016, and randomly divided into levosimendan group (n=36) and control group (n=34). The control group was treated with routine anti-CHF drugs, and levosimendan group, additionally with levosimendan. The curative effect was reviewed, and the levels of cardiac troponin T (cTnT), insulin-like growth factor-1 (IGF-1), N-terminal pro-brain natriuretic peptide (NT-proBNP), and indexes of left ventricular ejection fraction (LVEF), stroke volume (SV), left ventricular end-diastolic inner diameter (LVEDd) and left ventricular end-systolic diameter (LVESd) were detected in 2 groups before and after treatment.Results The total effective rate was 83.33% in levosimendan group and 73.53% in control group (P<0.05) after treatment. The levels of cTnT and NT-proBNP decreased and level of IGF-1 increased in 2 groups after treatment (allP<0.05). The levels of cTnT and NT-proBNP decreased and level of IGF-1 increased in levosimendan group compared with control group after treatment (allP<0.05). LVEF and SV increased in 2 groups after treatment (allP<0.05). SV increased in levosimendan group compared with control group [(76.32±15.37) mLvs. (65.45±13.58) mL] after treatment (P<0.05). There were no patients with adverse reactions observed in 2 groups.Conclusion Levosimendan administrated on the base of traditional drugs can significantly improve cardiac contractility and relieve myocardial injury with higher curative effect, which is worth clinical promoting.