The effects of bisoprolol on chromaffin grain protein A and cardiac function of heart failure patients with preserved left ventricular ejection fraction
ZHEN Yu-zhi
DENG Yan-dong
DUAN Li-nan
ZHAN Yin-ge
LIU Chao
LIU Kun-shen
Abstract：Objective To investigate the effects of bisoprolol on chromaffin granule protein A (CgA) in heart failure patients with preserved left ventricular ejection fraction (HFpEF), and to explore the role of CgA in HFpEF patients and the treatment effect of bisoprolol.Methods 66 chronic heart failure patients were randomly divided into treatment group and control group (33 patients in each group). Treatment group was given bisoprolol and standardized treatment, the control group was only given standardized treatment. CgA level and change of echocardiography were measured two weeks after treatment in two groups.Results There is no difference as to CgA level, left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), E peak, A peak, E/A and left ventricular isovolumic relaxation time (IVRT) between two groups before treatment (P>0.05). After treatment, all the indexes above in treatment group were improved better than control group (P<0.05). The total effective rate in treatment group was higher than control group (87.87%vs. 63.63%,P<0.05).Conclusion The effect of bisoprolol on HFpEF patients is remarkable. CgA is useful for condition judgment and prognosis of HFpEF patients.
Keywords：BisoprololHeart failureChromaffin granule protein A
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 919-921 )