Efficacy and safety of Shen Song Yang Xin Capsule for cardiac neurosis：a meta-analysis
LIU Hai-feng
DU Wu-xun
MAO Wen-yan
ZOU Jin-ming
WU Zi-tong
Abstract：Objective To evaluate the efficacy and safety of Shen Song Yang Xin Capsule for cardiac neurosis.Methods After searching by computer and manual work, the meta-analysis was performed using RevMan 5.2 software.Results There were 17 randomized controlled trials (RCTs) included, involving 1663 cardiac neurosis patients. The results of meta-analysis showed that, Shen Song Yang Xin Capsule combined with/without conventional western medicine (WM) could make a better efficacy (RR=1.29, 95%CI: 1.23~1.35) when compared with the conventional treatment. The total efficacy caused by treatment only with traditional Chinese medicine (TCM) was also superior to conventional WM (RR=1.34, 95%CI: 1.23~1.46). Gastrointestinal discomfort (3.93%) was the main adverse drug reaction (ADR) in TCM treatment, and abnormal blood pressure and heart rates (17.04%) were the main ADRs in conventional treatment based on reports of 6 studies. No significant difference was found in gastrointestinal discomfort (RR=1.81, 95%CI: 0.68~4.83), dizziness and flushing (RR=2.81, 95%CI: 0.30~26.38), headache (RR=0.17, 95%CI: 0.02~1.30) and fatigue (RR=0.08, 95%CI: 0.00~1.31) between two groups. But TCM treatment was superior to conventional treatment with respect to hypotension and bradycardia (RR=0.08, 95%CI:0.02~0.32). Treatment only with TCM was safer than conventional WM treatment (RR=0.26, 95%CI: 0.08~0.82). Conclusion Shen Song Yang Xin Capsule could improve the clinic symptom of cardiac neurosis safely and effectively. Further high-quality and large-scale RCTs are needed to confirm these results.
Keywords：Shen Song Yang Xin CapsuleCardiac neurosisMeta-analysisRandomized controlled trial
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 911-915 )