Expression of apelin in different types of coronary heart disease and the relationship between apelin and left ventricular remodeling
NI Ping
ZHAO Zhi-qiang
Abstract：Objective To investigate expression of apelin in patients with different types of coronary heart disease (CHD), and the relationship between apelin and left ventricular remodeling.Methods Ninety-nine patients initially admitted for CHD were divided into three groups: stable angina pectoris(SAP) group, unstable angina pectoris(UAP) group and acute myocardial infarction (AMI) group. Twenty-nine age matched patients with CHD excluded after coronary angiography(CAG) were involved as the control group. Plasma apelin levels were determined by enzyme-linked immunoabsorbent assay (ELISA). The left ventricular end systolic dimension (LVDs) and left ventricular end diastolic dimension (LVDd) were measured and recorded by the ultrasonic cardiography (UCG). Plasma apelin levels among four groups were compared. And relationship between plasma apelin levels of AMI, UAP, SAP groups with LVDs and LVDd were analyzed.Results Compared to the control group, plasma apelin in AMI group and UAP group was significantly lower (P<0.05). And there was no significant difference of plasma apelin between control group and SAP group (P>0.05). Among the AMI, UAP and SAP groups, plasma apelin level was significantly different (P<0.05). Plasma apelin was negatively correlated with LVDs and LVDd (r=-0.403 and-0.305 respectively,P<0.05).Conclusion Plasma apelin levels were different in different types of CAG, and plasma apelin level may be associated with the left ventricular remodeling.
Keywords：ApelinCoronary heart diseaseLeft ventricular remodelingLeft ventricular end systolic dimensionLeft ventricular end diastolic dimension
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 868-871 )