Mechanism of myocardial ischemia-reperfusion induced acute lung injury and protective effect of calcium dibutyryladenosine cyclophosphate
SUN Ze-gang
FENG Ze-rui
XU Ying-chun
CHEN Bao-zeng
WANG Yun-peng
Abstract：Objective To investigate the mechanism of myocardial ischemia and reperfusion induced acute lung injury (ALI) and protective effect of calcium dibutyryladenosine cyclophosphate.Methods During 2014.7-2015.12, 92 acute coronary syndrome (ACS) patients treated by percutaneous coronary intervention (PCI) were randomly divided into control group [25 males, 21 females and aged (65.3±12.6) ] and treatment group [26 males, 20 females and aged (63.6±12.4) ]. The control group was given PCI, and the IR flow was restored in TIMI III grade. Each patient in treatment group used calcium dibutyryladenosine cyclophosphate 40 mg daily from 2 days before PCI to 1 day after PCI. Interleukin-6(IL-6), Interleukin-8(IL-8), tumor necrosis factor-α(TNF-α), malondialdehyde (MDA), superoxide dismutase (SOD) concentration, respiratory index (RI), oxygenation index (OI) of 30 minutes (T1), 1h(T2), 6h(T3), 12h(T4) and 24h (T5) before PCI were compared.Results Compare with T1, RI in control group was higher at T2-T4 and OI was lower at T2-T5 (P<0.05), and there were no significant differences of RI and OI in Treatment group at T2-T5 (P>0.05). MDA ,IL-6 and IL-8 at T3-T5 and TNF-α at T2-T5 in control group were significantly higher. SOD in control group was lower at T3-T5 (P<0.05). IL-6 and IL-8 level at T3-T4, MDA level at T3-T5 and TNF -αlevel at T2-T4 in treatment group were significantly higher. SOD in the treatment group was lower at T3-T5 (P<0.05). Compare with control group, RI in treatment group was lower at T2-T4 and OI was higher at T2-T5 (P<0.05); MDA,SOD, IL-6, IL-8 level at T3-T5 and TNF-αlevel at T2-T5 in treatment group was significantly lower (P<0.05). IL-6, IL-8 level had positive correlation with RI (r=0.520,0.458, P<0.05), but had negative correlation with OI in control group (r=-0.612, -0.579,P<0.05).Conclusion Calcium dibutyryladenosine cyclophosphate mitigates acute lung injury induced by myocardial ischemia-reperfusion.
Keywords：Myocardial ischemia-reperfusionAcute lung injuryCalcium dibutyryladenosine cyclophosphateInflammatory
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 846-849 )