Short-term exposure to individual air pollutants associated with endothelial function in patients with metabolic syndrome
RUAN Yan-ping
ZHANG Lei
LIAN Hui
CAI Tian-qi
ZHAO Xiao-yi
SUN Li-xian
YAN Jian-hua
LIANG Rui-juan
ZHANG Yuan-xun
LIU Xiao-le
KONG De-hui
SUN Qing-hua
RAJAGOPALAN Sanjay
CAO Yang
CHENG Kang-an
FAN Zhong-jie
Abstract：Objective The cross-sectional study was conducted to detect the relationship of air pollutants with endothelial function.Methods There were 61 patients aged 62 years with metabolic syndrome enrolled in the study during Jan 26, 2013 to Jul 4, 2013. Endothelial function was performed by Endopat 2000 for all subjects, expressed as reactive hyperemia index (RHI). The detailed residential addresses have been obtained, which were used to model the individual concentration of the air pollutants by ArcGIS10.1 software based on the data of air pollutants from 35 fixed monitoring sites in Beijing, China. In addition, we got meteorological data from the China Meteorological Administration for the whole study period.Results The mean of individual air pollutants for all subjects was 78.2 μg/m3 for PM2.5, 129.6 μg/m3 for PM10, 52.9 μg/m3 for nitrogen dioxide (NO2), 25.0 μg/m3 for sulfur dioxide (SO2), 1.2μg/m3 for nitric oxide (CO) and 59.1 μg/m3 for ozone (O3) during Feb 2, 2013 to Jul 4, 2013. Multiple linear analysis has shown that decrease by 0.87 and 0.72 in RHI were associated with each 10μg/m3 increase in PM2.5 and PM10 for 15-day moving average (allP<0.05). No significant association was found RHI and gaseous air pollutants (allP>0.05). Conclusion Particulate air pollutants were associated with sub-acute impaired endothelial function in patients with metabolic syndrome. The way could, in part, account for the increases in cardiovascular disease morbidity and mortality seen in prior studies.
Keywords：Air pollutionPM2.5Endothelial functionMetabolic syndrome
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 792-796 )