A Meta-analysis on tumor necrosis factor-α C-857T polymorphism and susceptibility of coronary artery disease
ZHANG Peng
HOU Xiao-wen
HUANG Dong-hui
LI Guang-xiao
SHI Jing-pu
Abstract：Objective To investigate the relationship between tumor necrosis factor-α (TNF-α) C-857T polymorphism and susceptibility of coronary artery disease (CAD) by using Meta-analysis method.Methods The databases of PubMed, Web of Science, WanFang Database, Chongqing VIP and CNKI were retrieved until to Nov. 1, 2015. The eligible studies were given data extraction, quality review and Meta-analysis by using Stata 11.0 software. Results There were totally 7 documents included (totally 8 independent case-control studies) involved 2928 patients with CAD and 3495 control cases. The results of Meta-analysis showed that there was no statistical correlation between TNF-α C-857T polymorphism and susceptibility of CAD in whole population, while in Asian population and in hospital studies the correlation was observed. The analysis of sensitivity indicated that the results of this study were stable without publication bias.Conclusion TNF-α C-857T polymorphism may not be correlated to susceptibility of CAD, and more large-sample case-control studies are required for further identifying the results.
Keywords：Tumor necrosis factor-αPolymorphismCoronary artery diseaseSusceptibilityMeta-analysis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 777-780 )