The mechanism and effect of salvianolate on the proliferation of vascular intima
WANG Shu-qing
QIU Ming-ke
DAI Yu-xin
PAN Chang
WANG Yang
OU Jing-min
Abstract：Objective To observe the effect of salvianolate on the proliferation of vascular intima and study mechanism behind.Methods 18 SD rats were randomly divided into sham operation group, operation group, salvianolate group. After operation for 14 days, IL-6, IL-10, TNF-α and TGF-β levels were measured in serums, and pathological morphology of carotid artery sections were observed, including the intimal hyperplasia, intimal thickness (IT), Medium thickness (MT) and calculate IT/MT value. RT-PCR and Western Blot were used to measure the expression of LOX-1 mRNA and proteins in vascular.Results Intimal hyperplasia and vascular luminal stenosis were observed at 14 days in the rat carotid artery after vascular intimal injury. Compared with sham operation group, the expression of LOX-1 mRNA and proteins in operation group were increased in vascular walls (P<0.05). IL-6, TNF-α levels in serum were increased, while IL-10, TGF-β levels were decreased (P<0.05). Compared with the operation group, the intimal hyperplasia was significantly decreased in the salvianolate group, as well as serum IL-6 and TNF-α levels. However, IL-10 and TGF-β levels were increased (P<0.05), and LOX-1 mRNA and proteins expression level significantly were decreased (P<0.05). There was no statistic difference between salvianolate group and sham operation group in above items (P>0.05).Conclusion Salvianolate can effectively inhibit the intimal hyperplasia and inflammatory response after carotid artery injury, it may be related to the downregulation of the expression of LOX-1 in intimal hyperplasia.
Keywords：SalvianolateIntimal hyperplasiaInflammatory factorLOX-1
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 749-752 )