The correlation between iron deficiency and heart failure with preserved left ventricular ejection fraction
HUANG Nan-qing
ZHENG Xue-ou
Abstract：Objective To study the correlation between iron deficiency and heart failure with preserved left ventricular ejection fraction (HFpEF).Methods 179 HFpEF patients were enrolled. Ferritin, transferrin saturation, soluble transferrin receptor index and cardiac function index were tested. Participants were divided into iron deficiency group (n=61) and non-iron-deficiency group (n=118) based on the level of ferritin or transferrin saturation. The correlation between iron deficiency and HFpEF were studied.Results The difference of left atrium diameter (LAD) [(48.76±9.67)mmvs. (42.89±8.55)mm], ratio of early peak (E) to late peak (A) of mitral flow velocities (E/A) in cardiac ultrasound test [(1.14±0.35vs.(0.93±0.29)], N-terminal pro brain natriuretic peptide [NT-proBNP,(1903.14±123.27)pg/mlvs. (1601.23±115.93)pg/ml], 6-min-walk-test [6MWT, (351.71±74.27)mvs. (389.96±79.31)m], and NYHA heart function classification between two groups were statistically significant (P<0.05). There was a correlation between level of ferritin, transferrin saturation and soluble transferrin receptor index with LAD, E/A, NT-proBNP and 6MWT. The level of ferritin, transferrin saturation and soluble transferrin receptor index among different cardiac function classification were significantly different (P<0.05). Along with cardiac function classification increasing, level of ferritin and transferrin saturation was decreased, while soluble transferrin receptor index increased.Conclusion There is correlation between iron deficiency and HFpEF, it is necessary to screening iron deficiency in heart failure patients.
Keywords：Heart failure with preserved left ventricular ejection fractionIron deficiencyCorrelation
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 746-748 )