Influences ofATF6 and CHOP expression on left ventricular hypertrophy in hypertensive rats with hyperhomocystinemia and the effect of enalapril folic acid tablets intervention
LU Xuan-hao
ZHAO Lian-you
ZHANG Zhi-min
WANG Ji-peng
ZHOU Yan-fen
WANG Zeng-qiang
Abstract：Objective To Study the relationship between changes of activating transcription factor6 (ATF6) and C/EBP homologous protein (CHOP) expression with left ventricular hypertrophyin hypertension rats withhyperhomocy stinemia(HHcy) on myocardial endoplasmic reticulum stress(ERS),and observe the effect of enalapril folic acid tablets reversal left ventricular hypertrophy.Methods60 male SD rats underwent abdominal aortic constriction (AAC). Two weeks after operation,45 ratswhich systolic blood pressure(SBP)>140 mmHg were randomly divided into 3 groups. The AAC group was given normal diet and lavaged double distilled water; the control group was given 2.5% methionine diet and lavaged double distilled water; the treatment group received 2.5% methionine diet and lavaged enalapril folic acid tablets (10 mg/kg/d). SBP and blood homocysteine (Hcy) were measured regularly, echocardiographyexam ination was conducted, and the expression level of rat myocardial ATF6 protein and CHOP protein were detected by immunohistochemical and Western blot.Results 20 weeks after operation,the SBP, blood Hcy, inlet ventricular septal defect(IVSD) and left ventricular posterior wall diameter(LVPWD), expression of myocardial ATF6 and CHOPin the control group were higher than those in the AAC group (P<0.05); the SBP,blood Hcy, IVSD and LVPWD, myocardial ATF6 and CHOP expression in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Myocardial ATF6 and CHOP expressionin hypertension rats with HHcy was significantly higher than that in hypertensive ratswith normal Hcy, and CHOP expression was more dominant. Enalapril folic acid tablets can effectively reduce blood pressure and Hcy, mitigate myocardial ERS, relieve the myocardial hypertrophy.
Keywords：HypertensionHyperhomocystinemiaATF6CHOPMyocardial hypertrophyEnalapril folic acid tablets
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 729-732 )