Study of serum miR-208a expression in early stage of acute myocardial infarction and before and after PCI therapy
LIU Xin-xiu
GE Zhi-ru
ZHAO Han-jun
Abstract：Objective To investigate the change of serum miR-208a in early stage of acute myocardial infarction (AMI), before and after emergency percutaneous coronary intervention (PCI).Methods 30 AMI patients were selected as AMI group,20 healthy control from physical examination were selected as control group. Blood sample of AMI group were collected as the time of admission and 12hours after admission (in 6 hours after PCI), fasting blood sample of control group were collected in the morning. Expression of miR-208a were measured in the early stage of AMI, correlation analysis were conducted between miR-208a and expression level of cardiac troponin I and creatine kinase isoenzyme, and compared the change of miR-208a expression before and after PCI in AMI patients.Results Serum miR-208a level in AMI group was significantly higher than control group (P<0.05). Serum miR-208a level was positively associated with troponin I and creatine kinase isoenzyme (r1=0.356,P=0.045;r2=0.456,P=0.011). Serum miR-208a level was significantly reduced after PCI treatment (P<0.05).Conclusion Serum miR-208a level was significantly increased in early stage of AMI, but reduced after PCI treatment.
Keywords：miR-208aMyocardial infarctionTroponin ICreatine kinase isoenzyme
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 718-720 )