Changes of erythrocyte osmotic fragility in patients with acute ST-segment elevation myocardial infarction and postoperative no-reflow after emergency percutaneous coronary intervention
XUN Lei
LIU Hong-yan
QI Hua-xin
WANG Fang-ming
Abstract：Objective To investigate the relationship between the changes of erythrocyte osmotic fragility and postoperative no-reflow after emergency percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI).Methods STEMI patients (n=87, male 55 and female 32) were chosen from Jun. 2012 to Dec. 2014, and divided into no-reflow group (n=37) and reflow group (n=50). The fast vein blood was collected as detective samples from all patients before emergency PCI. The levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), minimum of erythrocyte osmotic fragility (OFmix) and maximum of erythrocyte osmotic fragility (OFmax), hemolysis ratio [0.45/0.15 (6th tube/11th tube), 0.45/0 (6th tube/12th tube)], activity of Na+-K+-ATP, malondialdehyde (MDA) and superoxide dismutase (SOD) were detected.Results OFmix and OFmax were significantly higher, and hemolysis ratio (0.45/0.15) and hemolysis ratio (0.45/0) were also significantly higher in no-reflow group than those in reflow group (allP<0.01). The level of MDA was significantly higher, and activity of Na+-K+-ATP and SOD were significantly lower in no-reflow group than those in reflow group (allP<0.01).Conclusion The erythrocyte osmotic fragility decreases significantly in STEMI patients with postoperative no-reflow after emergency PCI, which maybe one of post-PCI hypoperfusion causes. The decrease of erythrocyte osmotic fragility may be related to the decreases of activity of Na+-K+-ATP and SOD and increase of MDA level.
Keywords：Acute ST-segment elevation myocardial infarctionErythrocyte osmotic fragilityEmergency percutaneous coronary interventionNo-reflow
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 712-714 )