Study of values of GRACE risk score and NT-proBNP level for recent prognosis in patients with acute coronary syndromes
MA Hong
TANG Wan-chun
YOU Zhao-xiong
ZHAO Feng
WANG Li-qing
Abstract：Objective To study the value of the global registered acute coronary events (GRACE) score and amino terminal brain natriuretic peptide precursor (NT-proBNP) levels in patients with acute coronary syndrome (ACS) for recent prognosis.Methods 160 patients with ACS were enrolled between January 2013 and December 2013 from the fourth affiliated hospital of Inner Mongolia medical university. Baseline information were collected as when patients be hospitalized as well as GRACE score. Patients were divided into low risk group (GRACE score ≤108, 26 patients), medium risk group (GRACE score between 109 and 140, 58 patients), and high risk group (GRACE score >140, 76 patients). NT-proBNP level was measured. Incidence of major adverse cardiac events (MACE) was recorded during follow-up. Multivariate logistic regression was used to analyze correlation between recent prognosis and GRACE score or NT-proBNP level.Results Among three groups, significant difference was shown with respect to age, NT-proBNP level and GRACE score (P<0.05). Incidence of MACE during hospitalization and 30 days’ follow-up were different among three groups (P<0.01), the highest incidence rate occurred in high risk group. Results of linear regression showed that GRACE score was positively associated with NT-proBNP level (r=0.580、P<0.001,regression coefficientb=19.719、P<0.001). Results of multivariate logistic regression analysis showed that GRACE score, NT-proBNP level, age, smoking and hyperlipidemia are risk factors of MACE (P<0.05). Conclusion GRACE score and NT-proBNP level was positively correlated, and they were valuable for recent prognosis in patients with ACS.
Keywords：Acute coronary syndromeN-terminal brain natriuretic peptideGRACE scoreMajor adverse cardiovascular events
Publication Date：2016-01-01
Pages：4( 700-703 )