Prevention effects of loading-dose atorvastatin before emergency PCI on contrast induced nephropathy
YANG Yong
ZHAO Qing
LUO Jian-ping
LIU Hui-liang
YANG Sheng-li
SHEN Zhi-qi
HUANG Jie
Abstract：Objective To explore the effects of loading-dose atorvastatin on contrast induced nephropathy (CIN) in ST-segment elevation myocardial infarction (STEMI) patients.Methods STEMI patients who prepared for emergency PCI were randomly divided into three groups: Group A (received atorvastatin 80 mg loading dose before PCI and followed by 40 mg/d), Group B (received atorvastatin 40 mg/d after PCI) and Group C (received atorvastatin 20 mg/d after PCI). The incidence of CIN was calculated and compared among three groups. In addition, Serum creatinine (Cr), superoxide dismutase (SOD) and malondialdehyde (MDA) were measured.Results 384 patients were enrolled and randomly divided into three groups (Group A:n=131; Group B:n=124; Group C:n=129). No differences were found in baseline characteristics (P>0.05). Incidence of CIN in in Group A was lower than those in Group B or Group C (P<0.05). The levels of SOD and MDA in Group A were significantly higher than those in Group B or Group C on 24 hours, 3rd day and 7th day after emergency PCI (P<0.05), but no differences were seen among three groups 1 month after emergency PCI (P>0.05). No difference of severe adverse reactions was observed during the follow-up period.Conclusion For STEMI patients who were performed for emergency PCI, administration of 80 mg atorvastatin before emergency PCI reduced the incidences of CIN. It could be related with the anti-oxidative effect of atorvastatin.
Keywords：AtorvastatinST segment elevated myocardial infarctionContrast induced nephropathy
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 683-686,699 )