Efficacy and safety of second-generation of cryoballoon radiofrequency ablation in treatment of atrial fibrillation：a Meta-analysis

MEI Yu-hua; LI Jie; REN Peng

doi:10.3969/j.issn.1674-4055.2016.06.06

Abstract：Objective To review systematically the efficacy and safety of second-generation of cryoballoon radiofrequency ablation (G2) in treatment of atrial fibrillation (AF).Methods The databases of CNKI (1997~2015.4), WanFang Database (1989~2015.4), EMbase (1974~2015.4), PubMed (1966~2015.4), MedLine (1966~2015.4) and Cochrane Library (1989~2015.4) were retrieved for collecting case control studies on treatment of AF with G2. The observation group was treated with G2 and control group was treated with cold saline water perfusion catheter radiofrequency ablation (RF). The odds ratio (OR) of success rate of pulmonary vein isolation and AF non-recurrent rate 12 m after ablation between 2 groups were taken as effective indicators, weighted mean difference (WMD) of X-ray exposure time (min) and ablation procedure duration (min), and OR of major complication incidence were taken as safety indexes for Meta-analysis.Results There were totally 5 clinical control studies included involved 2049 patients (1117 in G2 group and 932 in RF group). The results of Meta-analysis showed that the success rate of pulmonary vein isolation was higher in G2 group than that in RF group (OR=2.54,95%CI:1.31~4.89,P=0.005,I2=0%). The AF non-recurrent rate 12 m after ablation had no significant difference between both groups (OR=0.71,95%CI:0.44~1.16,P=0.17,I2=67%). The incidence of major complications had no significant difference between both groups (OR=2.73,95%CI:1.00~7.46,P=0.05,I2=72%). X-ray exposure time had no significant difference between both groups (WMD=0.72,95%CI:-4.50~5.95,P=0.79,I2=96%), and ablation procedure duration had no significant difference between both groups (WMD=-20.37,95%CI:-48.92~8.18,P=0.16,I2=97%). Conclusion The efficacy and safety of second-generation of cryoballoon radiofrequency ablation are similar to those of saline water perfusion catheter radiofrequency ablation.