Influence of hyperhomocysteinemia on blood pressure variability and left ventricular remodeling in elderly patients with essential hypertension
WANG Dong
ZHANG Wen
Abstract：Objective To observe the influence of hyperhomocysteinemia on blood pressure variability (BPV) and left ventricular remodeling in elderly patients with essential hypertension. Methods The elderly patients with essential hypertension (n=61, male 36, female 25 and average age=66.5±6.8) were chosen from May 2014 to May 2015, and then were divided, according to the level of plasma homocysteine (Hcy), into H-type group (n=27) and non-H-type group (n=34). The indexes of BPV (24 h BP variation coefficient, daytime BP variation coefficient and nighttime BP variation coefficient) and indexes of left ventricular remodeling [left ventricular end-diastolic inner diameter (LVEDd), left ventricular end-systolic diameter (LVESd), left ventricular posterior wall thickness (LVPWT), interventricular septal thickness (IVST) and left ventricular ejection fraction (LVEF)] were compared between 2 groups. Results There was no difference in average age, sex, body mass index, smoking history and percentages of cases of diabetes and hyperlipidemia between 2 groups (P>0.05). The indexes of BPV (24 h BP variation coefficient, daytime BP variation coefficient and nighttime BP variation coefficient) were higher in H-type group than those in non-H-type(P<0.05). The level of plasma Hcy was positively correlated to 24 h systolic blood pressure variation coefficient (r=0.373, P<0.05) in H-type group, and percentage of cases of left ventricular hypertrophy was significantly higher in H-type group than that in non-H-type (25.93% vs. 8.82%, P<0.05). LVEDd, LVESd, LVPWT, IVST and left ventricular mass index (LVMI) were all higher in H-type group than those in non-H-type (P<0.05). The level of plasma Hcy was positively correlated to LVMI (r=0.325, P<0.05) and LVPWT (r=0.284, P<0.05) in H-type group. Conclusion Hyperhomocysteinemia shows positive correlation to increased BPV and left ventricular remodeling in elderly patients with essential hypertension.
Keywords：HyperhomocysteinemiaSenile essential hypertensionBlood pressure variabilityLeft ventricular remodeling
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 615-618 )