Level of interleukin-6 and sex hormone is related to severity of coronary artery calcium in postmenopausal female
XU Min
ZOU Bao-ming
XU Feng
WANG Jing-wu
SUN Ke-lu
LIANG Ai-xia
LI Bin-bin
WU Yong-liang
Abstract：Objective To investigate relationship between sex hormones, interleukin 6 (IL-6) level and severity of coronary artery calcium in postmenopausal female. Methods 142 newly diagnosed female patients with coronary heart disease (CHD) who were postmenopausal over 2 years were enrolled. All patients received coronary artery computerized tomography (CT), and were divided into two groups: the experiment group (97 cases with coronary artery calcification), and the control group (45 cases without coronary artery calcification). And based on the coronary artery calcium score(CACS), the experiment group was further divided into 3 groups: the low CACS group (CACS 1-100,26 cases), the medium CACS group (CACS 101-400,49 cases), the high CACS group (22 cases). Blood estradiol (E2), testosterone (T) and interleukin 6 (IL-6) were measured and then analyzed in all groups. Results Compared with the control group, E2 of experiment group was significantly decreased, and IL-6 was significantly increased (P<0.05). No difference of T was shown in experiment group and control group (P>0.05). With the aggravating degree of coronary artery calcium score, the serum E2 level is gradually reduced; the level of IL-6 is gradually increased (P<0.05). No difference of T was shown among three CACS groups (P>0.05). Conclusion The degree of coronary artery calcium in postmenopausal women is highly related with IL-6 and E2. E2 may help to curb the development of CHD by inhibiting the expression of the inflammation activity of the coronary.
Keywords：Coronary artery calciumEstradiolInterleukin-6PostmenopausalFemale
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 610-612 )