Effects of lyophilized recombinant human brain natriuretic peptide on heart rate variability and endothelial function in elder acute myocardial infarction patients
ZHANG Hui
ZHANG Ye
LI Dan-dan
Fu Zhen-hong
Abstract：Objective To explore the effects of lyophilized recombinant human brain natriuretic peptide (Lrh-BNP) on heart rate variability (HRV) and endothelial function in elder acute myocardial infarction (AMI) patients. Methods 104 AMI patients over 60 years old were divided into study group and control group, each group contains 52 patients. Patients in control group were treated with conventional drugs and patients in study group were treated with conventional drugs plus intravenous Lrh-BNP injection. Nitric oxide (NO) and endothelin-1 (ET-1) and brachial arterial endothelium-dependent diastolic function were detected. The time domain and frequency domain were analyzed in study group and control group. Results The brachial arterial endothelium-dependent diastolic function was significantly better in study group than in control group after treatment. The serum NO level was significantly higher while the serum ET-1 level was significantly lower in study group than in control group (P<0.05). After treated with Lrh-BNP,HRV and time-domain analysis in study group revealed a significant improvement in SDNN、SDANN、RMSSD (P<0.05). Frequency domain (LF and HF) were also improved (P<0.05). Conclusion Lrh-BNP can improve endothelial function and the declined HRV in a dramatic way, and can also decrease the incidence of cardiac insufficiency.
Keywords：Acute myocardial infarctionLyophilized recombinant human brain natriuretic peptideHeart rate variabilityEndothelial function
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 596-598,601 )