Influence of ticagrelor on Tp-e and ratio of Tp-e to QTc in patients with STEMI before and after emergency PCI
ZHANG Ming-liang
SHEN Yu-hua
WANG Huan-yu
YIN Shi
LI Da-peng
WANG Li-heng
Abstract：Objective To discuss the influence and clinical significance of oral loading dose of ticagrelor before emergency percutaneous coronary intervention (PCI) and oral maintenance dose of ticagrelor after emergency PCI on Tp-e and ratio of Tp-e to QTc (Tp-e/QTc) in patients with ST-segment elevation myocardial infarction (STEMI).Methods The patients with definitive diagnosed STEMI (n=68) were chosen and randomly divided into ticagrelor group and clopidogrel group (eachn=34). The changes of Tp-e and Tp-e/QTc were observed before PCI and 24 h after PCI.Results Among 68 patients, there were 22 with ventricular arrhythmias (AV) before emergency PCI and on one with AV after emergency PCI. Tp-e and Tp-e/QTc were significantly longer in AV patients than those in non-AV patients (P<0.05). Tp-e and Tp-e/QTc were significantly shorter after PCI than before in clopidogrel group (P<0.05) and also in ticagrelor group (P<0.01). The shortening of Tp-e and Tp-e/QTc was more significant in ticagrelor group compared with clopidogrel group (P<0.05).Conclusion The decreases of Tp-e and Tp-e/QTc are more significant in STEMI patients given loading dose of ticagrelor before emergency PCI and oral maintenance dose of ticagrelor after emergency PCI. The incidence of AV is correlated to the extension of Tp-e and Tp-e/QTc in STEMI patients.
Keywords：Acute myocardial infarctionTicagrelorTp-eRatio of Tp-e to QTc
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 489-491 )