Influences of Tongxinluo Capsules combining telmisartan on vascular endothelial function and oxidative stress in patients with hypertension

ZHANG Xiao-dong

doi:10.3969/j.issn.1674-4055.2016.03.33

Abstract：Objective To investigate the influences of Tongxinluo Capsules combining telmisartan on vascular endothelial function and oxidative stress in patients with hypertension.Methods The patients with hypertension (n=102) were randomly divided into control group (n=50) treated with telmisartan (40 mg once a day and increased to 80 mg if blood pressure being not controlled) and observation group (n=52) treated with telmisartan (40 mg once a day) and Tongxinluo Capsules (3 capsules twice a day) for 12 w. The levels of total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), superoxide dismutase (SOD), malondialdehyde (MDA), von Willebrand factor (vWF), endothelin-1 (ET-1) and nitric oxide (NO) were detected and compared in 2 groups before and after treatment.Results After treatment for 12 w, the levels of systolic blood pressure (SBP) and diastolic blood pressure (DBP) decreased significantly in 2 groups (P<0.05). The levels of TC, LDL-C, HDL-C, MDA, SOD and vWF had significant changes (allP>0.05), and levels of NO and ET-1 decreased significantly in control group after treatment (P<0.05). The levels of TC, LDL-C, MDA, vWF and ET-1 decreased significantly and levels of HDL-C, SOD and NO increased significantly in observation group after treatment (all P<0.05). Compared with control group, the levels of MDA, vWF and ET-1 decreased significantly and levels of SOD and NO increased significantly in observation group after treatment (allP<0.05). The difference in the incidence of adverse reactions had no statistical significance between 2 groups (P>0.05).Conclusion Tongxinluo Capsules combining telmisartan can effectively reduce the level of oxidative stress, improve vascular endothelial function and prolong hypertension development in treatment of hypertension.