Curative effect of oral ibuprofen in premature infants with patent ductus arteriosus reviewed by echocardiogram
LI Xiang-nong
JIANG Ming-hong
LIU Xue-mei
WANG Kun
Abstract：Objective To review the curative effect of oral ibuprofen in premature infants with patent ductus arteriosus (PDA) by echocardiogram.Methods The premature infants with diagnosed PDA (n=46) were randomly divided into treatment group (n=25) given oral ibuprofen and control group (n=21) without immediate treatment. After 7 d, all patients were given reexamination of echocardiogram for observing the closure status of PDA.Results PDA was closed in 19 cases and not closed in 6 cases in treatment group, and spontaneously closed in 10 cases and 11 did not closed in 11 cases in control group. The closure rate was 76% in treatment group and 47.6% in control group (P<0.05). There was no adverse reaction observed in treatment group.Conclusion Oral ibuprofen has higher effective rate in premature infants with PDA reviewed by echocardiogram, and there is no adverse reaction observed.
Keywords：EchocardiogramPremature infantsPatent ductus arteriosusIbuprofen
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 361-363 )