Curative effect of fructose diphosphate in children patients with congenital heart disease complicating heart failure
LI Guang-chao
JIN Xuan
Abstract：Objective To observe the curative effect of fructose diphosphate (FDP) in children patients with congenital heart disease (CHD) complicating heart failure (HF).Methods The children patients with CHD complicating HF (n=150) were randomly divided into observation group and control group (eachn=75). The control group was given digitalis, furosemide and captopril other conventional treatment, and observation group was additionally given FDP intravenous drip [70 mg/(kg·min)]. The curative effect, heart function indexes and adverse reactions were compared in 2 groups after treatment for 5 d.Results There were 45 cases with significant efficacy, 27 with curative effect, and 3 without curative effect. The effectual rate was 60.0% and total effective rate was 96.0% in observation group. There were 36 cases with significant efficacy, 27 with curative effect, and 12 without curative effect. The effectual rate was 48.0% and total effective rate was 82.7% in control group. The difference was statistically significant between 2 groups (P<0.05). The comparison in heart function indexes before and after treatment showed that left ventricular ejection fraction (LVEF), left ventricular end-systolic diameter (LVESd) and stroke volume (SV) were significantly improved in 2 groups (P<0.05). The improvements of LVEF and LVESd were more significant in observation group after treatment (P<0.05). The incidence of adverse reactions was lower in observation group than that in control group (P<0.05).Conclusion FDP can significantly relieve clinical symptoms and improve heart function in children patients with CHD complicating HF.
Keywords：Fructose diphosphateCongenital heart disease in childrenHeart failure
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 358-360 )