Changes of serum fractalkine, matrix metalloproteinase-9 and monocyte chemoattractant protein-1 in patients with coronary heart disease
GE Hui-juan
ZHUANG Xiao-sai
NING Bin
Abstract：Objective To observe the changes of serum fractalkine (FKN), matrix metalloproteinase-9 (MMP-9) and monocyte chemoattractant protein-1 (MCP-1) in patients with coronary heart disease (CHD). Methods CHD patients (n=144, male 74, female 70 and average age=64.9±10.1) were chosen from Jun. 2014 to Oct. 2014. The patients were divided into stable angina pectoris group (SAP group,n=45), unstable angina pectoris group (UAP group,n=55) and acute myocardial infarction (AMI group,n=44). Other 50 heath controls were chosen as control group. The levels of FKN, MMP-9 and MCP-1 were detected by using enzyme-linked immunosorbent assay (ELISA).Results Compared with control group, the levels of FKN, MMP-9 and MCP-1 increased significantly in SAP group, UAP group and AMI group (allP<0.05). Compared with SAP group, the levels of FKN, MMP-9 and MCP-1 increased significantly in UAP group and AMI group (allP<0.05). Compared with UAP group, the levels of FKN, MMP-9 and MCP-1 increased significantly in AMI group (all P<0.05).Conclusion The levels of serum FKN, MMP-9 and MCP-1 increase significantly in CHD patients, which is helpful for monitoring the severity of CHD.
Keywords：Coronary heart diseaseFractalkineMatrix metalloproteinase-9Monocyte chemoattractant protein-1
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 349-351 )