Influence of rosuvastatin on rats with acute myocardial infarct
SUN Yao
HUO Yan-hui
YU Xiao-long
LIU Shan-shan
Abstract：Objective To observe the therapeutic effect of rosuvastatin on rats with acute myocardial infarct (AMI).Methods SD rats (n=60) were randomly divided into sham-operation group only given opening and closing chest treatment and oral normal saline solution once a day for 1 w, rosuvastatin group prepared as AMI model and given rosuvastatin (5 mg/kg) once a day for 1 w, and mode group prepared as AMI model and given normal saline solution 1 w before operation once a day for 1 w (eachn=20). The number of death rats (died within 1 h after operation) were counted. The expressions of serum interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α) and cardiac troponin T (cTnT) were detected by using ELISA after operation for 8 h.Results There were 56 survived and 4 died among 60 SD rats. There was 1 died due to respiratory failure and 2 due to arrhythmias in model group, and 1 died due to anesthetic accident in rosuvastatin group. Compared with sham-operation group, the levels of IL-8, TNF-α and cTnT increased in model group and rosuvastatin group (allP<0.05). Compared with model group, the levels of IL-8 [(552.91±35.61) μl/mLvs. (264.00±39.25) μl/mL], TNF-α [(767.99±33.58) μl/mLvs. (370.14±32.31) μl/mL] and cTnT [(562.58±33.17) μl/mLvs. (161.56±31.43) μl/mL] decreased in rosuvastatin group after treatment (allP<0.05). After operation for 4 w, left ventricular weight (LVW), percentage of LVW to whole heart weight and whole heart weight increased in model group and rosuvastatin group compared with sham-operation group after treatment (allP<0.05). Compared with model group, percentage of LVW to whole heart weight [(88.20±3.17)%vs. (73.45±2.31)%] decreased in rosuvastatin group (P<0.05), which indicated that rosuvastatin had some relieving effect on left ventricular hypertrophy.Conclusion Rosuvastatin can relieve inflammation and left ventricular hypertrophy after AMI in rats.
Keywords：RosuvastatinAcute myocardial infarctRats
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 347-348,351 )