Relationship among serum growth differentiation factor-15, creatine kinase MB, cardiac troponin I and myoglobin in patients with acute myocardial infarction
RONG Wen-ming
Abstract：Objective To discuss the relationship among serum growth differentiation factor-15 (GDF-15), creatine kinase MB (CK-MB), cardiac troponin I (cTnI) and myoglobin (Mb) in patients with acute myocardial infarction (AMI).Methods AMI patients (n=127, male 71, female 56, aged from 51 to 82 and average age=71.28 ±10.83) were chosen as observation group from Dec. 2013 to Dec. 2014. Meanwhile the healthy controls with physical examinations (n=104, male 62, female 42, aged from 50 to 84 and average age=70.02±11.76) were chosen as control group. The levels of serum GDF-15, CK-MB, cTnI and were detected in 2 groups.Results The level of serum GDF-15 was significantly higher in observation group than that in control group [(3.04±1.09) g/Lvs. (0.41± 0.13) g/L,P<0.01]. Compared with control group, the levels of cTnI, CK-MB and Mb increased [(0.31±0.11) g/L (3.82±1.53) g/L], [(16.53±5.09) g/Lvs. (45.07±13.16) g/L] and [(40.17±4.15) g/Lvs. (201.11±45.62) g/L] in observation group (allP<0.05). The results of Pearson correlation analysis showed that level of serum GDF-15 was positively correlated to cTnI, CK-MB and Mb (r=0.427,r=0.409,r=0.511, allP<0.05).Conclusion The levels of serum GDF-15, cTnI, CK-MB and Mb all increase in AMI patients, and GDF-15 is positively correlated to cTnI, CK-MB and Mb. GDF-15 may be a new diagnostic index for AMI.
Keywords：Acute myocardial infarctionGrowth differentiation factor-15Cardiac troponin ICreatine kinase MB
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 344-346 )