Efficacy of levosimendan on chronic heart failure
QU Feng-xia
LI Ping
AN Yi
GUO Xiao
LIANG Lei
LU Chang-hong
Abstract：Objective To observe the curative effect of levosimendan on chronic heart failure (CHF).Methods CHF patients (n=64, male 35, female 29, aged from 39 to 79 and average age=58.76±12.89) were chosen from Sept. 2014 to Sept. 2015, and then randomly divided into observation group and control group (eachn=32). The control group was given traditional anti-CHF therapy, and observation group was additionally given levosimendan injection. The changes of left ventricular ejection fraction (LVEF) and N-terminal pro brain natriuretic peptide (NT-proBNP) were detected before and after treatment, and curative effect of levosimendan was reviewed.Results There were 11 cases (34.4%) with significant curative effect and 11 (34.4%) with curative effect, and the total effective rate was 68.8%in control group. There were 12 cases (37.6%) with significant curative effect and 15 (46.8%) with curative effect, and the total effective rate was 84.4% in observation group. The difference was significant statistically between 2 groups (P<0.05). The level of LVEF increased and level of NT-proBNP decreased in 2 groups after treatment (allP<0.05). Compared with control group, LVEF [(36.31±7.39)%vs. (39.87±6.74)%] increased and NT-proBNP [(5904.23 ±1027.35) pg/mlvs. (5418.06±1008.40) pg/ml] decreased in observation group after treatment (allP<0.05). The difference in incidence of adverse reactions had no statistical significance between 2 groups (P>0.05).Conclusion Levosimendan combining traditional therapy has higher curative effect than only traditional therapy, which can significantly improve heart function and relieve myocardial injury in CHF patients.
Keywords：Chronic heart failureLevosimendanLeft ventricular ejection fractionN-terminal pro brain natriuretic peptide
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 342-344 )