Curative effect of insulin pump in elderly patients with type 2 diabetes mellitus complicating pulmonary infection

YAO Lu; WU Yun-tao; WANG Xiao-bing; ZHANG Feng; ZHANG Wei

doi:10.3969/j.issn.1674-4055.2016.03.24

Abstract：Objective To observe the clinical efficacy of insulin pump in elderly patients with type 2 diabetes mellitus (T2DM) complicating pulmonary infection.Methods The patients (n=60, male 42, female 18, aged from 61 to 85 and average age=69.4±6.8) were chosen from Nov. 2013 to Jun. 2015, and then randomly divided into control group and treatment group (eachn=30). The control group was given multiple subcutaneous injection of insulin, and treatment group was given continuous infusion of insulin by using insulin pump. The level of blood glucose was compared, and insulin dosage and incidence of hypoglycemia were recorded in 2 groups before and after treatment.Results The level of blood glucose decreased significantly at different time points in 2 groups after treatment for 3 d and 15 d (allP<0.01). After treatment for 3 d, the level of blood glucose decreased more significantly at different time points in treatment group compared with control group (allP<0.05): fasting plasma glucose [(6.3±1.2) mmol/Lvs. (8.6±2.0) mmol/L], plasma glucose 2 h after breakfast [(8.0±2.0) mmol/Lvs. (9.5 ±2.2) mmol/L], plasma glucose 0.5 h before supper [(6.2±1.6) mmol/Lvs. (8.3±2.1) mmol/L] and plasma glucose before sleeping [(6.9±1.4) mmol/Lvs. (9.0±2.0) mmol/L]. After treatment for 15 d, the difference in level of blood glucose had no statistical significance at different time points between 2 groups (allP>0.05). Compared with control group, the dosage of insulin was less, and the incidence of hypoglycemia was lower in treatment group (all P<0.05). Conclusion Insulin pump can control well the level of plasma glucose with less insulin dosage and lower incidence of hypoglycemia in patients with T2DM complicating pulmonary infection.