Influence of sequential therapy of ticagrelor and clopidogrel on platelet aggregation rate and major adverse cardiovascular events in patients with STEMI undergone emergency PCI
ZHANG Ming-liang
SHEN Yu-hua
WANG Huan-yu
YIN Shi
LI Da-peng
WANG Li-heng
Abstract：Objective To investigate the influence of sequential therapy of ticagrelor and clopidogrel on platelet aggregation rate (PAG) and major adverse cardiovascular events (MACE) in patients with ST-segment elevation myocardial infarction (STEMI) undergone emergency PCI.Methods The patients with STEMI (n=92) were chosen from Feb. 2012 to Mar. 2015, and then randomly divided into ticagrelor group (given orally ticagrelor, n=30), clopidogrel group (given orally clopidogrel,n=30) and sequential therapy group (given orally ticagrelor at first and clopidogrel after 7 d,n=32). The changes of PAG were detected before PCI and after PCI for 2 h, 24 h, 7 d and 30 d, and incidence of MACE and bleeding events were observed within 30 d.Resutls After PCI, PAG decreased significantly in 3 groups (P<0.05). At the time points of 2 h, 24 h and 7 d after PCI, PAG decreased more significantly in ticagrelor group compared with clopidogrel group (P<0.05). At the time points of 2 h, 24 h, 7 d and 30 d, the difference in PAG had no statistical significance between sequential therapy group and ticagrelor group (P>0.05). The incidence of MACE within 30 d was lower in ticagrelor group and sequential therapy group than that in clopidogrel group (P<0.05). The incidence of bleeding events had no significant difference among 3 groups during hospitalization (P>0.05).Conclusion Before emergency PCI, anti-platelet therapy with ticagrelor applied in STEMI patients can significantly inhibit platelet aggregation, reduce MACE within 30 d, and cannot increase bleeding risk. Clopidogrel is orally given to STEMI patients for replacing ticagrelor 7 d after PCI has the same curative effect.
Keywords：Acute myocardial infarctionTicagrelorClopidogrelMajor adverse cardiovascular eventsPlatelet aggregation rate
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 331-334 )