Clinical significance of changes of extravascular lung water in patients with neurogenic pulmonary edema
JIANG Jia-shu
TANG Zhan-hong
ZHANG Chi
Abstract：Objective To investigate the clinical significance of changes of extravascular lung water (EVLW) in patients with neurogenic pulmonary edema (NPE), and review the prognosis meaning of EVLW index (EVLWI) to NPE patients.Methods NPE patients (n=42) were chosen from Jan. 2010 to Mar. 2013.The changes of EVLWI and pulmonary vascular permeability index (PVPI) were detected by using pulse indicator continuous cardiac output (PICCO), and difference in EVLWI, PVPI and oxygenation index (OI) were compared before and after treatment. The correlation among EVLWI, PVPI and OI was analyzed. The patients were divided, according to their outcomes, into survival group and death group, and the difference in EVLWI was compared between 2 groups before and 7 d after treatment.Results EVLWI decreased significantly (P<0.05), PVPI decreased significantly (P<0.05) and OI increased significantly (P<0.05) in 2 groups after treatment for 3 d, 5 d and 7 d. EVLWI and PVPI were, respectively, correlated negatively to OI (r=-0.509,P<0.05;r=-0.541, P<0.001). EVLWI was correlated positively to PVPI (r=0.712,P<0.01). EVLWI had no statistical difference between survival group and death group before treatment (9.4±3.1vs. 10.1±2.7,P>0.05). After treatment for 7 d, EVLWI decreased significantly in survival group (6.2±2.0vs. 9.4±3.1,P<0.01), which was lower than that in death group (6.2±2.0vs. 8.4±1.7,P<0.05). Conclusion The level of EVLW can directly reflect the severity of disease in NPE patients. The higher EVLW was, the more severe the disease was and the lower the OI was. At the same time EVLWI can predict mortality.
Keywords：Neurogenic pulmonary edemaExtravascular lung waterPulmonary vascular permeability indexOxygenation index
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 308-310 )