Addministration of etomidate in non-cardiac surgery in elderly patients with heart disease
WANG Zhen-yu
CHEN Si
YANG Fu-guo
QI Zheng
ZENG Yi
Abstract：Objective To investigate the feasibility of etomidate administrated in non-cardiac surgery in elderly patients with heart disease.Methods The elderly patients with heart disease undergone laparoscopic cholecystectomy under general anesthesia (n=60) were chosen from Nov. 2014 to Aug. 2015, and randomly divided, according to ASA grading, into etomidate group (E group) and propofol group (P group, eachn=30). During anesthesia induction, E group was given etomidate (0.2 mg/kg~0.3 mg/kg) and P group was given propofol (1 mg/kg~2 mg/kg). The changes of monitored invasive artery pressure (MAP), heat rate (HR), cardiac output (CO), cardic index (CI), stroke volume (SV) and stroke variation index (SVI) were recorded before anesthesia induction (T1) and at moment of tracheal intubation (T2), 3 min after anesthesia induction (T3), procedure starting time (T4), time of pneumoperitoneum establishment (T5), time of gallbladder excision (T6) and finishing time of procedure (T7). Results The general condition, dosage of anesthetics, and revive time had no statistical difference between two groups (P>0.05). Compared with E group, MAP and HR decreased significantly at time points of T2 and T3 (P<0.05), CO, CI and SV decreased significantly at time points from T2 to T6 (P<0.05), and SVI increased significantly at time points from T2 to T6 (P<0.05) in P group.Conclusion The general anesthesia with etomidate can well maintain stable hemodynamics and reduce anesthesia risk in non-cardiac surgery in elderly patients with heart disease.
Keywords：Heart diseaseNon-cardiac surgeryNon-invasive cardiac outputIntravenous anesthesiaEtomidate
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 287-289 )