Correlation among homocysteine, brain natriuretic peptide (BNP) and risk stratification of chronic heart failure
LUO Chun-miao
Gao Chao
FENG Jun
Abstract：Objective To analyze the changes of levels of homocysteine (Hcy) and brain natriuretic peptide (BNP), and correlation among them and risk stratification of chronic heart failure (CHF).Methods CHF patients (n=93) were chosen continuously from Feb. 2012 to Dec. 2014 as CHF group, and other patients without CHF (n=61) were chosen at the same time as control group. CHF group was divided again into II-grade subgroup (n=48), III-grade subgroup (n=28) and IV-grade subgroup (n=22) according to NYHA grading method. The levels of Hcy and BNP were detected in all groups. The changes of left ventricular mass (LVM) were detected by using color Doppler echocardiogram, and left ventricular mass index (LVMI) was calculated. The difference in Hcy level was analyzed between CHF group and control group and among all subgroups. The correlation between Hcy and BNP or LVMI was studied.Results The levels of Hcy and BNP was significantly higher in CHF group than those in control group (P<0.05). As the increase of NYHA grade, the levels of Hcy and BNP increased significantly (P<0.05). Hcy was correlated positively to BNP or LVMI (r=0.382,P<0.05).Conclusion The changes of serum Hcy level can reflect the changes of CHF to some extent.
Keywords：Chronic heart failureHomocysteineBrain natriuretic peptid
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 280-282 )