The change of plasma GDF-15 level in acute myocardial infarction patients and its clinical significance

Zhao Ding-xue; Miao Yun-feng; Gong Bi-feng

doi:10.3969/j.issn.1674-4055.2016.02.32

Abstract：Objective To investigate the change of plasma growth differentiation factor-15 (GDF-15) level and its clinical significance in patients with acute myocardial infarction (AMI).Methods From February 2014 to February 2015, 127 patients (observation group) treated in Hanzhong Central Hospital were selected (age from 51 to 82 years old). 74 cases were ST segment elevation myocardial infarction patients (STEMI group), and 53 cases were non ST segment elevation myocardial infarction patients (NSTEMI group). 104 healthy people in the same hospital were selected as healthy controls. Plasma GDF-15, myocardial infarction three indicators [isoenzyme of creatine kinase (CK-MB), troponin I (cTnI), myoglobin (MB) and left ventricular remodeling index (LVRI) were tested in all groups.Results Plasma GDF-15 in AMI group was (3.04±1.09) g/L, which is significantly higher than the control group (P<0.05). Plasma GDF-15 in STEMI group was (3.30±1.10) g/L, which is significantly higher than NSTEMI group (P<0.05). The cTnI, CK-MB and Mb were (3.82±1.53) g/L, (45.07±13.16) g/L and (201.11±45.62) g/L in AMI group, which were significantly higher than the control group (P<0.05). The cTnI, CK-MB and Mb were (4.07±1.37) g/L, (48.13±17.49)g/L and (210.07±34.27) g/L in STEMI group, which were significantly higher than NSTEMI patients (P<0.05). Plasma GDF-15 was positively correlated with CK-MB, cTnI and Mb (r=0.427, 0.409, 0.511,P<0.05); and GDF-15 was positively correlated with change rate of LVRI (r=0.303,P<0.05). However, there was no correlation between CK-MB, cTnI, Mb and change rate of LVRI (P>0.05).Conclusion Plasma GDF-15, cTnI, CK-MB and Mb in AMI patients were increased, and especially in STEMI patients. GDF-15 is associated with cTnI, CK-MB and Mb, and is associated with LVRI. GDF-15 has certain value in AMI diagnosis.