Comparison of the Effects of Urapidil and Nicardipine Application Among Middle and Old Aged Acute Hypertension Patients

Zhang Lei; Ma Tao; Li Xia

doi:10.3969/j.issn.1674-4055.2016.02.25

Abstract：Objective To compare the effects of urapidil and nicardipine in middle and old aged acute hypertension patients.Methods 100 middle and old aged acute hypertension patients from emergency department of the fifth affiliated hospital f Xinjiang Medical University between Dec.2013 to Dec.2013 were divided into four groups. Group A included middle-aged patients with urapidil (n=25); Group B included middle-aged patients with nicardipine (n=25); Group C included elderly patients with urapidil (n=25); Group D included elderly patients with nicardipine (n=25). The 24h ambulatory blood pressure (PP), the pulse pressure index (PPI), the heart rate (HR),the smoothness index (SI) of the systolic and diastolic blood pressures (SISBP and SIDBP) after treatment were collected. And level of norepinephrine, epinephrine, serum brain natriuretic peptide and angiotensin II were tested before and after treatment. The remission time of symptoms of hypertension was also recorded.Results Comparing with group A, 24h PP, PPI, HR and SI of group B were reduced significantly (P<0.05). Comparing with group D, the indexes above of group C were reduced significantly (P<0.05). NA and Adr levels in the peripheral blood of group A and C had no significant fluctuations (P>0.05). Serum NA and Adr levels were elevated in both group B and D (P<0.05). After treatment, the concentrations of BNP and AngII decreased in all groups. In elderly patients with urapidil, the change was more significant (P<0.05). In middle-aged patients with nicardipine, the change was more significant (P<0.05). The remission time of symptoms of hypertension in elderly patients with urapidil and middle-aged patients with nicardipine was shorter.Conclusion For better effects, elderly patients may choose urapidil, and middle-aged patients may use nicardipine.