The intervention effects of rosuvastatin for coronary heart disease patients with Hyperlipoidemia

Xie Yan

doi:10.3969/j.issn.1674-4055.2016.02.24

Abstract：Objective To compare the effects between Rosuvastatin and simvastatin on blood lipid and high sensitive C reactive protein (hs-CRP) among patients with coronary heart disease (CHD).Methods 236 patients (male/female=144/92, age=57~81, average age=62.4±12.7) with CHD and hyperlipoidemia were collected from 2013.04~2014.04 from Deshengmen Community Health Centre of Xicheng District of Beijing, and divided into rosuvastatin group (observation group) and simvastatin group (control group). The low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), total cholesterol (TC), apolipoprotein A1 (Apo A1), apolipoprotein B (Apo B), high-sensitivity C-reactive protein (hs-CRP), blood urea nitrogen (BUN), serum creatinine (Cr), alanine aminotransferase (ALT), creatine kinase (CK) of the two groups were observed.Results No significant differences (P>0.05) were observed in sex, age, complications (including high blood pressure, diabetes), and indexes of blood lipid. Compared to control group, TG, TC, LDL-C, hs-CRP, Apo A1, Apo B were decreased, and HDL-C was increased significantly in observation group after treatment (P<0.05). No significant differences were Cr and BUN in observation group and control group after 12 weeks’ treatment (P>0.05). And none cardiovascular eventwas observed during treatment and follow-up.Conclusion Rosuvastatin is more effectively and safer reducing blood lipids and hs-CRP than simvastatin.