Influence of the Atrial pacing stimulation to Left Heart Function and NT-proBNP
WU Yong-liang
ZOU Bao-ming
WANG Jing-wu
XU Feng
XU Min
SUN Ke-lu
LIANG Ai-xia
Abstract：Objective To observe the influence of the current stimulation of atrial electrodes from a pacing on the N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac function and structure.Methods All selected cases were checked, in accordance with permanent pacemaker implantation class I or class type IIa indications. Atrial electrodes are implanted into the right atrium, while the ventricle electrode is in the right ventricular inlet septum. Atrioventricular all-around pacemaker mode (atrial pacemaker electrode, Group DDD) is set at postoperative period; atrial synchronous ventricular inhibition mode (atrial electrode of pacemaker, Group VDD) is on three months after the operation with 10-days observation period. Detecting the blood NT- proBNP before the adjustment, after the observation period respectively, after the observation period respectively and at the same using the intracoronary Doppler ultrasound to measure the following: left atrium diameter(LAD), left ventricular end-diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD) and left ventricular ejection fraction (LVEF). To ensure patients’ safety and the accuracy of the result, the ventricular pacing at the low limit frequency of 45 times/min is set after shutting down the atrial pacing electrode, and the pacing equal or greater than 40% during the observation period is not in our research any more. A total of 95 people participate in our research via the self-contrast method.Results After shutting down the atrial electrode, the NT-proBNP values are reduced accordingly [(94.61,197.11)ng/Lvs.(86.32,128.36)ng/L,P=0.00]; LVEF values of patients decrease after the observation period from the previous [(55.47±6.10)%vs. (51.27±5.68)%,P=0.03]; The LAD Values[(26.55,33.05)mmvs.(26.80,35.80)mm,P=0.09]and the LEVDD Values[(46.25,50.50)mm vs.(47.55,53.65)mm,P=0.12] increase from the previous .Conclusion The double chamber pacemaker inserted on the patient has a promoting effect on the NT-proBNP secreted by the atrium while the atrial electrode is working, which could play a positive role in improving the cardiac function of patients.
Keywords：PacemakerArtificialAtrial electrodesN-terminal pro-brain natriuretic peptide
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 202-205 )