Detection and review of short-term stroke risk after transient ischemic attack with ABCD3 scoring method combining homocysteine
ZHANG Lei
LUO Guo-jun
TANG Chun-lei
LIU Zhen
TANG Ding-zhong
HU Can-fang
Abstract：Objective To discuss the review value of ABCD3 scoring method combining homocysteine (Hcy, ABCD3+Hcy) to the risk of short-term stroke after transient ischemic attack (TIA).Methods TIA patients (n=285) were chosen from Jan. 2012 to Jan. 2015, and scored for risk stratification by applying ABCD2 scoring method (ABCD2), scoring method (ABCD3) and ABCD3+Hcy. The incidence of stroke was recorded within 2 d and within 7 d after TIA. The receiver operating characteristic curve (ROC) was drawn and area under curve (AUC) was observed. The values of ABCD2, ABCD3 and ABCD3+Hcy were reviewed.Results AUC of stroke risk within 2 d after TIA was 0.702 (95%CI: 0.579~0.818) in ABCD2, 0.783 (95%CI: 0.671~0.895) in ABCD3 and 0.846 (95%CI: 0.751~0.935) in ABCD3+Hcy, and AUC was the largest in ABCD3+Hcy (P<0.05). AUC of stroke risk within 7 d after TIA was 0.757 (95%CI: 0.662~0.849) in ABCD2, 0.833 (95%CI: 0.746~0.913) in ABCD3 and 0.873 (95%CI: 0.805~0.951) in ABCD3+Hcy, and AUC was the largest in ABCD3+Hcy (P<0.05). The percentage of stroke within 7 d after TIA was 28.8% among 285 cases, and incidence rate of stroke was 55.8% in high-risk group, 21.9%in mid-risk group and 3.8% in low-risk group (P<0.05).Conclusion ABCD2, ABCD3 and ABCD3+Hcy have some clinical values in reviewing the risk of short-term stroke after TIA, and veracity of ABCD3+Hcy is higher than other 2 methods in predicting stroke risk, which is worth clinical application.
Keywords：ABCD3 scoring methodHomocysteineTransient ischemic attackStroke
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 197-199 )