The change of right ventricular function before and after interventional treatment in atrial septal defect patients

Lin Bin; Zhang Qiang; Liu Cheng-fei; Zhou Jing

doi:10.3969/j.issn.1674-4055.2016.02.20

Abstract：Objective To evaluate difference of right heart function before and after interventional therapy among adult atrial septal defect (ASD) patients.Methods 40 ASD patients from Yancheng Third People's Hospital between 2013.01 and 2014.01 were included as observation group (22 males and 18 females, average age=39.2 ±11.3). Another 40 healthy adult volunteers were involved as control group (20 males and 20 females, average age=40.1±10.9). No significant differences of sex and age were observed in both groups (P>0.05). Interventional therapy was conducted in observation group. right ventricular end-diastolic area (AreaED), right ventricular end systolic area (AreaES), tricuspid valve systolic peak velocity (S'), tricuspid valve systolic displacement (TAPSE) were measured using echocardiography and calculated RVFAC before surgery, one day after surgery and six months after surgery.Results Before the treatment, AreaED, AreaES, S' and TAPSE in control group were less than observation group, and RVFAC in control group RVFAC was greater than observation group (P<0.05). AreaED [(27.88±7.54)cm2vs.(23.86±6.52)cm2vs.(21.02±5.46)cm2], AreaES [(16.22±5.30)cm2vs.(14.12 ±2.36)cm2vs.(11.02±2.12)cm2], TAPSE [(2.98±0.76)cmvs.(2.38±0.44)cmvs.(2.34±0.54)cm] in observation group were decreased in one-day and six months after treatment (P<0.05). S' in observation group in one-day and six months after treatment was lower than before (P<0.05). Compare to RVFAC in observation before the treatment, it was lower in one day after treatment (P<0.05), but higher after six months (P<0.05).Conclusion For patients with ASD, the interventional therapy could improve the right ventricular diastolic and systolic function.