The effects of amino-terminal pro-B-type natriuretic peptide precursor contents and circulating endothelial particles of Qiliqiangxin capsule on elderly patients with heart failure
Qiu Chang-zhi
Lu Yong-guang
Abstract：Objective To investigate the effects of amino-terminal pro-B-type natriuretic peptide precursor (NT-ProBNP) contents and circulating endothelial particles (EMP) of Qiliqiangxin capsule on elderly patients with heart failure.Methods 120 elderly patients with heart failure from the Second People,s Hospital of Qinzhou City between 2013.01~2014.12, were randomly divided into treatment group and control group. The control group were received standard treatment, the treatment group were given standard treatment and Qiliqiangxin capsules. The duration of treatment was one month for both groups. The changes of NT-ProBNP, C reactive protein (CRP) and EMP were compared between two groups.Results After treatment, the response rates in treatment group was significantly higher than control group (96.7%vs. 81.7%,P<0.05). After treatment, the left ventricular ejection fraction (LVEF) and E/A ratio values were significantly increased (P<0.05), while the LVEF and E/A ratio values in the treatment group were significantly higher (P<0.05). After treatment, the plasma CRP and EMP levels were significantly lower (P<0.05), while the plasma CRP and EMP levels in the treatment group were significantly lower than the control group (P<0.05). After treatment, the plasma NT-ProBNP levels and circulating endothelial particles were decreased significantly in both groups (P<0.05), while the plasma NT-ProBNP levels in the treatment group were significantly lower than the control group (P<0.05).Conclusion Qiliqiangxin capsule treatment of elderly patients with heart failure can improve heart function, improve the therapeutic efficacy.
Keywords：Qiliqiangxin capsuleElderlyHeart failureAmino-terminal pro-B-type natriuretic peptide precursorEndothelial microparticles
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 168-171 )