Level of high-sensitivity C-reactive protein in patients with hypertension complicating obstructive sleep apnea syndrome：a Meta-analysis
ZHAO Ying-ke
ZHANG Jing-chun
LIU Yue
WU Chun-xiao
MA Lin-qin
ZHANG Hui
LV Chang-xia
LEI Shu-yan
Abstract：Objective To investigate the level of high-sensitivity C-reactive protein (hs-CRP) in patients with hypertension complicating obstructive sleep apnea syndrome (OSAS).Methods The databases of PubMed, Cochrane Library, EMbase, CBM, CNKI, WanFang Database and VIP Database were retrieved with computer until Dec. 2014 for collecting the case-control studies on hs-CRP detection in patients with hypertension complicating OSAS. All eligible studies were given quality review, data extract and Meta-analysis by using Revman5.3.5 software.Results There were totally 15 studies included involving 2739 cases. The results of Meta-analysis showed that the level of hs-CRP was significantly higher in patients with hypertension complicating OSAS than that in health people (SMD=1.08, 95%CI: 0.68~1.49,P<0.01), and also significantly higher than that in patients with only OSAS (SMD=0.59, 95%CI: 0.31~0.68,P<0.01) and than that in patients with only hypertension (SMD=0.38, 95%CI: 0.24-0.52,P<0.01). The level of hs-CRP was higher in patients with hypertension complicating mild, medium or serious OSAS than that in control group (P<0.05), and the level of hs-CRP showed an ascending trend as severity of OSAS increased.Conclusion OSAS can exacerbate inflammatory reactions in patients with hypertension, and the severity of OSAS may be related to level of hs-CRP.
Keywords：HypertensionObstructive sleep apnea syndromeHigh-sensitivity C-reactive proteinMeta-analysis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 144-149 )